Pseudomonas aeruginosa: So many virulence factors, so little time*

So Many WAM Variations, So Little Time

So Many Zebras, So Little Time:

So many questions, so little time.

Fifteen years have elapsed since the first human infections with H5N1 highly pathogenic avian influenza (HPAI) virus were detected in Hong Kong SAR, China [1, 2]. Many of these human infections were fatal and represented the first documented outbreak of severe disease due to HPAI viruses. The hallmark of these H5N1 viruses is their hemagglutinin genes inherited from A/goose/Guangdong/1996, a vi...

Yeast two-hybrid: so many interactions, (in) so little time...

Protein-protein interactions are essential to cellular mechanisms at all levels in biologically responsive systems. These interactions occur extracellularly and include ligand-receptor interactions, cell adhesion, antigen recognition, and virus-host recognition. Intracellular protein-protein interactions occur in the formation of multi-protein complexes, during the assembly of cytoskeletal elem...

So Many Factors , so Little Time . . . Simulation Experiments in the Frequency Domain

We illustrate how an efficient methodology called frequency domain experimentation can be used to gain better insight into the behavior of production systems. With the full factorial designs commonly used for simulation experiments, the number of runs grows exponentially with the number of factors involved, while the run length remains constant. In frequency domain experiments, the number of ru...